Alys Jarvela
Research Interests
evo-devo, transcription factor evolution, gene regulatory networks, evolution of novel traits
Publications
Cheatle Jarvela, A.M., Trelstad, C. S. and Pick, L. (2020) Regulatory gene function handoff allows essential gene loss in mosquitoes. Communications Biology 3, 540 (2020). https://doi.org/10.1038/s42003-020-01203-w
Reding, K., Chen, M., Lu, Y., Cheatle Jarvela, A.M., & Pick, L. (2019) Shifting roles of Drosophila pair-rule gene orthologs: segmental expression and function in the milkweed bug Oncopeltus fasciatus. Development. 146: dev181453 doi: 10.1242/dev.181453 [Link]
Splinter K, Adams DR, Bacino CA, Bellen HJ, Bernstein JA, Cheatle-Jarvela AM, Eng CM, Esteves C, Gahl WA, Hamid R, Jacob HJ, Kikani B, Koeller DM, Kohane IS, Lee BH, Loscalzo J, Luo X, McCray AT, Metz TO, Mulvihill JJ, Nelson SF, Palmer CGS, Phillips JA 3rd, Pick L, Postlethwait JH, Reuter C, Shashi V, Sweetser DA, Tifft CJ, Walley NM, Wangler MF, Westerfield M, Wheeler MT, Wise AL, Worthey EA, Yamamoto S, Ashley EA; Undiagnosed Diseases Network. (2018). Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease. N Engl J Med. 2018 Oct 10. doi: 10.1056/NEJMoa1714458.
Cary, G.A., Cheatle Jarvela, A.M., Francolini, R.D., and Hinman, V.F. (2017). Genome-wide use of high- and low-affinity Tbrain transcription factor binding sites during echinoderm development. PNAS 201610611.
Cheatle Jarvela, A.M., and Pick, L. (2017). The Function and Evolution of Nuclear Receptors in Insect Embryonic Development. Curr. Top. Dev. Biol. 125, 39–70.
Cheatle Jarvela, A.M., and Pick, L. (2016). Evo-Devo: Discovery of Diverse Mechanisms Regulating Development. Curr. Top. Dev. Biol. 117, 253–274.
Cheatle Jarvela, A.M., Yankura, K.A., and Hinman, V.F. (2016). A gene regulatory network for apical organ neurogenesis and its spatial control in sea star embryos. Development dev.134999.
Cheatle Jarvela, A.M., and Hinman, V.F. (2015). Evolution of transcription factor function as a mechanism for changing metazoan developmental gene regulatory networks. EvoDevo 6, 3.
Cheatle Jarvela, A.M., Brubaker, L., Vedenko, A., Gupta, A., Armitage, B.A., Bulyk, M.L., and Hinman, V.F. (2014). Modular Evolution of DNA-Binding Preference of a Tbrain Transcription Factor Provides a Mechanism for Modifying Gene Regulatory Networks. Mol Biol Evol 31, 2672–2688.
Cheatle Jarvela, A.M., and Hinman, V. (2014). A method for microinjection of Patiria miniata zygotes. J Vis Exp e51913.
Hinman, V.F., and Cheatle Jarvela, A.M. (2014). Developmental gene regulatory network evolution: insights from comparative studies in echinoderms. Genesis 52, 193–207.
Yankura, K.A., Koechlein, C.S., Cryan, A.F., Cheatle, A., and Hinman, V.F. (2013). Gene regulatory network for neurogenesis in a sea star embryo connects broad neural specification and localized patterning. PNAS 110, 8591–8596.
Kunttas-Tatli, E., Zhou, M.-N., Zimmerman, S., Molinar, O., Zhouzheng, F., Carter, K., Kapur, M., Cheatle, A., Decal, R., and McCartney, B.M. (2012). Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo. Genetics 190, 1059–1075.
Martincic, K., Alkan, S.A., Cheatle, A., Borghesi, L., and Milcarek, C. (2009). Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing. Nat. Immunol. 10, 1102–1109.
Reding, K., Chen, M., Lu, Y., Cheatle Jarvela, A.M., & Pick, L. (2019) Shifting roles of Drosophila pair-rule gene orthologs: segmental expression and function in the milkweed bug Oncopeltus fasciatus. Development. 146: dev181453 doi: 10.1242/dev.181453 [Link]
Splinter K, Adams DR, Bacino CA, Bellen HJ, Bernstein JA, Cheatle-Jarvela AM, Eng CM, Esteves C, Gahl WA, Hamid R, Jacob HJ, Kikani B, Koeller DM, Kohane IS, Lee BH, Loscalzo J, Luo X, McCray AT, Metz TO, Mulvihill JJ, Nelson SF, Palmer CGS, Phillips JA 3rd, Pick L, Postlethwait JH, Reuter C, Shashi V, Sweetser DA, Tifft CJ, Walley NM, Wangler MF, Westerfield M, Wheeler MT, Wise AL, Worthey EA, Yamamoto S, Ashley EA; Undiagnosed Diseases Network. (2018). Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease. N Engl J Med. 2018 Oct 10. doi: 10.1056/NEJMoa1714458.
Cary, G.A., Cheatle Jarvela, A.M., Francolini, R.D., and Hinman, V.F. (2017). Genome-wide use of high- and low-affinity Tbrain transcription factor binding sites during echinoderm development. PNAS 201610611.
Cheatle Jarvela, A.M., and Pick, L. (2017). The Function and Evolution of Nuclear Receptors in Insect Embryonic Development. Curr. Top. Dev. Biol. 125, 39–70.
Cheatle Jarvela, A.M., and Pick, L. (2016). Evo-Devo: Discovery of Diverse Mechanisms Regulating Development. Curr. Top. Dev. Biol. 117, 253–274.
Cheatle Jarvela, A.M., Yankura, K.A., and Hinman, V.F. (2016). A gene regulatory network for apical organ neurogenesis and its spatial control in sea star embryos. Development dev.134999.
Cheatle Jarvela, A.M., and Hinman, V.F. (2015). Evolution of transcription factor function as a mechanism for changing metazoan developmental gene regulatory networks. EvoDevo 6, 3.
Cheatle Jarvela, A.M., Brubaker, L., Vedenko, A., Gupta, A., Armitage, B.A., Bulyk, M.L., and Hinman, V.F. (2014). Modular Evolution of DNA-Binding Preference of a Tbrain Transcription Factor Provides a Mechanism for Modifying Gene Regulatory Networks. Mol Biol Evol 31, 2672–2688.
Cheatle Jarvela, A.M., and Hinman, V. (2014). A method for microinjection of Patiria miniata zygotes. J Vis Exp e51913.
Hinman, V.F., and Cheatle Jarvela, A.M. (2014). Developmental gene regulatory network evolution: insights from comparative studies in echinoderms. Genesis 52, 193–207.
Yankura, K.A., Koechlein, C.S., Cryan, A.F., Cheatle, A., and Hinman, V.F. (2013). Gene regulatory network for neurogenesis in a sea star embryo connects broad neural specification and localized patterning. PNAS 110, 8591–8596.
Kunttas-Tatli, E., Zhou, M.-N., Zimmerman, S., Molinar, O., Zhouzheng, F., Carter, K., Kapur, M., Cheatle, A., Decal, R., and McCartney, B.M. (2012). Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo. Genetics 190, 1059–1075.
Martincic, K., Alkan, S.A., Cheatle, A., Borghesi, L., and Milcarek, C. (2009). Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing. Nat. Immunol. 10, 1102–1109.
Education
Doctor of Philosophy in Biological Sciences, 2014
Carnegie Mellon University, Pittsburgh, Pennsylvania.
Bachelor of Science in Biochemistry, 2008
The Catholic University of America, Washington, DC
Carnegie Mellon University, Pittsburgh, Pennsylvania.
Bachelor of Science in Biochemistry, 2008
The Catholic University of America, Washington, DC
Contact
ajarvela(at)umd(dot)edu